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• MeltDB 2.0

  A software platform for the Analysis and Integration of Data from Metabolomics Experiments

  To facilitate the systematic storage, analysis and integration of metabolomics experiments, we have implemented MeltDB, a web-based software platform for the analysis and annotation of datasets from metabolomics experiments. MeltDB supports open file formats (netCDF, mzXML, mzDATA) and facilitates the integration and evaluation of existing preprocessing methods. The system provides researchers with means to consistently describe and store their experimental datasets. Comprehensive analysis and visualization features of metabolomics datasets are offered to the community through a web-based user interface. The system covers the process from raw data management to the visualization of results in a knowledge-based background and is integrated into the context of existing software platforms of the junior group for computational genomics at Bielefeld University.

  A short summary of MeltDB key features

  Store & organize experimental data
  Upload chromatogram data from different file formats (netCDF, mzXML, mzDATA) and organize these into chromatogram groups (e.g. replicates) and experiments.

  Project and user management
  Have your data secured or share it with other project members using the fine-grained project and user management.

  Feature extraction & preprocessing
  Peak detection, chromatogram alignment and profiling are offered within the flexible MeltDB tool pipeline.

  Compound identification & quantitation
  Identify compounds according to database matches (NIST, GMD) and/or create and use your own reference lists. For quantitation area and intensity of peaks can be normalized to internal standards (e.g. Ribitol).

  Explorative & statistical analysis
  A multitude of data visualizations and statistical tools can be applied to your processing results. Among these are significance tests, clustering algorithms, machine-learning tools and others.

  Integration with omics data
  An interface to the ProMeTra software allows to fuse your results from metabolomics with transcriptomics or proteomics data.

• Journal articles on MeltDB

  Find publications on MeltDB or MeltDB features here. Citations of MeltDB or biology-scoped publications not included.

  Bioinformatics. 2008 Dec 1;24(23):2726-32. doi: 10.1093/bioinformatics/btn452. Epub 2008 Sep 2.

  MeltDB: a software platform for the analysis and integration of metabolomics experiment data.

  Neuweger H, Albaum SP, Dondrup M, Persicke M, Watt T, Niehaus K, Stoye J, Goesmann A.
  Metabolomics. 2012 Apr 8;2:310-22. doi: 10.1007/s11306-011-0311-6.

  MSEA: metabolite set enrichment analysis in the MeltDB metabolomics software platform: metabolic profiling of Corynebacterium glutamicum as an example

  Persicke M, Rückert C, Plassmeier J, Stutz LJ, Kessler N, Kalinowski J, Goesmann A, Neuwerger H.
  Bioinformatics first published online August 5, 2013 doi:10.1093/bioinformatics/btt414

  MeltDB 2.0 - Advances of the metabolomics software system.

  Kessler N, Neuweger H, Bonte A, Langenkämper G, Niehaus K, Nattkemper TW, Goesmann A.

• The MeltDB wiki

  Find information and tutorials about specific tools in the MeltDB wiki.

  Video tutorials

  For the first steps in MeltDB, there are video tutorials available.

• Contact

  Please contact the MeltDB support team for questions concerning MeltDB, or to obtain your own account for MeltDB.
  
  » meltdb-service[at]cebitec.uni-bielefeld.de
  
  

  Postal Adress

  BRF - Bioinformatics Resource Facility
  Universität Bielefeld
  CeBiTec
  33594 - Bielefeld